Formulation: A solid
Formal Name: 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-benzamide
Purity: ≥98%
Formula Markup: C23H16N4O
Formula Weight: 364,4
Shelf life (days): 1460
CAS Number: 781652-57-1
Notes: CDPPB is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5).{63060} It potentiates glutamate-induced increases in intracellular calcium in CHO cells expressing mGluR5 (EC50s = 10 and 20 nM for the human and rat receptor, respectively). CDPPB (30 mg/kg, s.c.) inhibits amphetamine-induced disruptions in prepulse inhibition (PPI) of the acoustic startle response in rats.