Formulation: A solid
Formal Name: 2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]-quinoline
Purity: ≥98%
Formula Markup: C22H25N3
Formula Weight: 331,5
Shelf life (days): 1460
CAS Number: 57961-90-7
Notes: Centhaquin is a resuscitative agent.{51372} It binds to serotonin (5-HT) receptors in isolated rat cerebral cortex and brainstem membranes (Kis = 178.9 and 103.7 nM, respectively).{51373} Centhaquin (0.05-0.45 mg/kg) increases the latency to tail-flick in mice, an effect that can be reversed by the α2A-adenergic receptor (α2A-AR) antagonist BRL 44408 (Item No. 29454) and α2B-AR antagonist imiloxan but not the α2C-AR antagonist JP-1302 (Item No. 25974).{51374} It increases mean arterial blood pressure (MAP), cardiac output, and survival following bleeding-induced hypotension in a rat model of hemorrhagic shock when administered at doses ranging from 0.006 to 0.05 mg/kg in combination with hypertonic saline.{51372}
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