Formulation: A solid
Formal Name: P-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-P-(phenylmethyl)-phosphinic acid, monohydrochloride
Purity: ≥98%
Formula Markup: C18H22Cl2NO3P • HCl
Formula Weight: 438,7
Shelf life (days): 1460
CAS Number: 149184-22-5
Notes: CGP 55845 is a GABAB receptor antagonist (Ki = 4.5 nM).{68553} It increases electrical stimulation-induced GABA release in the absence and presence of the GABAB receptor agonist (–)-baclofen, as well as glutamate release in the presence of (–)-baclofen, in rat cerebral cortex slices (EC50s = 8.3, 25, and 14 nM, respectively). CGP 55845 (1 µM) inhibits (–)-baclofen-induced postsynaptic hyperpolarization of evoked inhibitory postsynaptic potentials (IPSPs) and field excitatory postsynaptic potentials (fEPSPs) in rat CA1 hippocampal slices.{68554} It increases swimming time, but does not decrease immobility time, in the forced swim test in rats when administered at a dose of 3 or 10 mg/kg.{68555} CGP 55845 (0.01 and 0.1 mg/kg) reverses age-induced impairments in olfactory discrimination learning in rats.{68556} It increases seizure intensity in a mouse model of epilepsy induced by pentylenetetrazole (PTZ; Item No. 18682) kindling.{68557}
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