CH 275 (acetate)

Formulation: A solid

Formal Name: L-cysteinyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-4-[[(1-methylethyl)amino]methyl]-L-phenylalanyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine, cyclic (1→11)-disulfide, acetate

Purity: ≥95%

Formula Markup: C74H96N14O15S2 • XC2H4O2

Formula Weight: 1485,8

Shelf life (days): 1460

Notes: CH 275 is a cyclic peptide agonist of somatostatin receptor 1 (SST1; IC50 = 30.9 nM for the human receptor).{51825} It is selective for SST1 over SST2, SST3, SST4, and SST5 (IC50s = >10,000, 345, >1,000, and >10,000 nM, respectively, for the human receptors). CH 275 (500 nM) inhibits basal growth hormone secretion from primary mouse pituitary cells.{51826} It inhibits glucose-induced increases in electrical activity without inducing membrane hyperpolarization in a whole-cell patch-clamp assay using MIN6 pancreatic β-cells when used at a concentration of 100 nM.{51827}

• SKU: CAY41050-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41050-1
• Package Unit: 1 mg
• Quantity Unit: STK