Chenodeoxycholic Acid (sodium salt), CAS 2646-38-0

Formulation: A solid

Formal Name: (5β)-3α,7α-dihydroxy-cholan-24-oic acid, monosodium salt

Purity: ≥95%

Formula Markup: C24H39O4 • Na

Formula Weight: 414,6

Shelf life (days): 1460

CAS Number: 2646-38-0

Notes: Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid.{59331} It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay.{13291,9823} It induces transcription of the gene encoding the Nrf2 target glutamate cysteine ligase (GCL) in primary hepatocytes and HepG2 cells when used at concentrations ranging from 25 to 100 µM.{16793}

• SKU: CAY35346-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35346-500
• Green Labware: No
• Package Unit: 500 mg
• Quantity Unit: STK
• Application: Reinstoffe