Chlormethiazole (hydrochloride), CAS 6001-74-7

Formulation: A crystalline solid

Formal Name: 5-(2-chloroethyl)-4-methyl-thiazole, monohydrochloride

Purity: ≥98%

Formula Markup: C6H8ClNS • HCl

Formula Weight: 198,1

Shelf life (days): 1460

CAS Number: 6001-74-7

Notes: Chlormethiazole is a potentiator of GABAA receptors.{60313} It potentiates GABA-induced currents in L-M(TK-) cells expressing α1β1γ2 or α1β2γ2 subunit-containing GABAA receptors with EC50 values of 0.8 and 3.4 µM, respectively. Chlormethiazole protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 130.8 mg/kg).{60314} It reduces infarct volume in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO).{60315} Formulations containing chlormethiazole have been used in the treatment of acute alcohol withdrawal.

• SKU: CAY33437-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33437-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK