Notes: Chlormethiazole is a potentiator of GABAA receptors.{60313} It potentiates GABA-induced currents in L-M(TK-) cells expressing α1β1γ2 or α1β2γ2 subunit-containing GABAA receptors with EC50 values of 0.8 and 3.4 µM, respectively. Chlormethiazole protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 130.8 mg/kg).{60314} It reduces infarct volume in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO).{60315} Formulations containing chlormethiazole have been used in the treatment of acute alcohol withdrawal.