Formulation: A solid
Formal Name: 2-chloro-N,N-di(methyl-d3)-10H-phenothiazine-10-propanamine, monohydrochloride
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C17H13ClD6N2S • HCl
Formula Weight: 361,4
Shelf life (days): 1460
CAS Number: 1228182-46-4
Notes: Chlorpromazine-d6 (CPZ-d6) is intended for use as an internal standard for the quantification of CPZ (Item No. 16129) by GC- or LC-MS. CPZ is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM).{23093,24252} It is also an antagonist of histamine H1, α1A-, α2B-, and α2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively).{24253} CPZ (10 mg/kg per day) increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats.{43329} CPZ (0.3, 1, and 3 mg/kg, s.c.) also reduces emesis induced by cisplatin (Item No. 13119) in dogs.{43330}
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