Formulation: A crystalline solid
Formal Name: [C(E)]-N-[(2-chloro-5-thiazolyl)methyl]-N′-methyl-N′′-nitro-guanidine
Purity: ≥98%
Formula Markup: C6H8ClN5O2S
Formula Weight: 249,7
Shelf life (days): 1460
CAS Number: 210880-92-5
Notes: Clothianidin is a neonicotinoid insecticide and an active metabolite of the prodrug thiamethoxam (Item No. 25784).{45017} It binds to nicotinic acetylcholine receptors (nAChRs; IC50 = 0.6 nM for housefly head membranes) and activates non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = 1,520 nM). Clothianidin induces mortality in adult M. persicae (LC95 = 1.28 mg/L), as well as H. virescens and S. frugiperda second instar larvae when used at a concentration of 8 mg/L in a leaf-dip bioassay. In vivo, clothianidin (>25 mg/kg) increases the number of premature births in rabbits and reduces the length and weight of fathead minnows (P. promelas) when administered in tank water at a concentration of 20 mg/L.{53371} Formulations containing clothianidin have been used as insecticides in residential and agricultural settings.