Formulation: A solid
Formal Name: (11β,16α)-16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-[2-(methyl-d3)-1-oxopropoxy-2,3,3,3-d4]-pregna-1,4-diene-3,20-dione
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C32H37D7O7
Formula Weight: 547,7
Shelf life (days): 1460
CAS Number: 1225382-70-6
Notes: Ciclesonide-d7 is intended for use as an internal standard for the quantification of ciclesonide (CIC; Item No. 18227) by GC- or LC-MS. Ciclesonide is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
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