Formulation: A solid
Formal Name: N-cyano-N''-methyl-d3-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-guanidine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C10H13D3N6S
Formula Weight: 255,4
Shelf life (days): 1460
CAS Number: 1185237-29-9
Notes: Cimetidine-d3 is intended for use as an internal standard for the quantification of cimetidine (Item No. 18743) by GC- or LC-MS. Cimetidine is a histamine H2 receptor antagonist (Ki = 0.6 μM).{30325} It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 μM). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 μM).{30545} In vivo, it inhibits histamine-induced gastric acid secretion in gastric fistulae and Heidenhain pouches in dogs (ED50 = 1.88 μmol/kg, p.o.). Cimetidine (20 mg/kg per day) also reduces tumor growth and neovascularization in a CMT93 colon cancer mouse syngeneic model.{47643}
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