Formulation: A solid
Formal Name: (αR)-α-(methyl-d3)-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C22H19D3F3N • HCl
Formula Weight: 396,9
Shelf life (days): 1460
CAS Number: 2749807-20-1
Notes: Cinacalcet-d3 is intended for use as an internal standard for the quantification of cinacalcet (Item No. 16042) by GC- or LC-MS. Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).{26279} In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.{39827} Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.
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