Formulation: A solid
Formal Name: N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide, monohydrochloride
Purity: ≥98%
Formula Markup: C20H24N2OS • HCl
Formula Weight: 376,9
Shelf life (days): 1460
CAS Number: 54-84-2
Notes: Cinanserin is a serotonin (5-HT) receptor antagonist.{61112,61113} It inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum.{61112} Cinanserin inhibits 5-HT-induced gross excitation, gastric mucosal erosion, and anaphylactoid edema in mice and rats. Cinanserin (12 and 36 mg/kg, i.p.) impairs acquisition of a running response in rats trained for food reward.{61113} It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteinase (3CLpro; IC50 = 5 µM) and reduces SARS-CoV viral RNA levels in infected BHK-Rep-1 cells (IC50s = 19-34 µM).{61114} It also inhibits viral replication of murine hepatitis virus (MHV) in CCL-9.1 murine liver epithelial cells (IC50 = 31.25 µg/ml).{32157}
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