Formulation: A solid
Formal Name: 2-amino-3-oxo-3H-phenoxazine-4,6,7,8-d4-1,9-dicarboxylic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C14H4D4N2O6
Formula Weight: 304,3
Shelf life (days): 1460
Notes: Cinnabarinic acid-d4 is intended for use as an internal standard for the quantification of cinnabarinic acid (Item No. 11988) by GC- or LC-MS. Cinnabarinic acid is an agonist of metabotropic glutamate receptor 4 (mGluR4) and active metabolite of 3-hydroxyanthranilic acid.{23007,23004} It is formed via two-step oxidation of 3-hydroxyanthranilic acid. Cinnabarinic acid (100 µM) selectively induces inositol phosphate production in HEK293 cells expressing mGluR4 over HEK293 cells expressing mGluR1, mGluR2, mGluR5, mGluR6, mGluR7, or mGluR8.{23007} It inhibits D-amino acid oxidase (DAAO) in a cell-free assay (IC50 = 1.37 µM).{69171} Cinnabarinic acid (30 µM) increases levels of reactive oxygen species (ROS) and induces apoptosis in primary mouse thymocytes.{23006}
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