Formulation: A crystalline solid
Formal Name: 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(1-oxobutoxy)methyl] ester
Purity: ≥98%
Formula Markup: C21H23Cl2NO6
Formula Weight: 456,3
Shelf life (days): 1460
CAS Number: 167221-71-8
Notes: Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
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