Formulation: A solid
Formal Name: 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(1-oxobutoxy-d7)methyl] ester
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C21H16Cl2D7NO6
Formula Weight: 463,4
Shelf life (days): 1460
CAS Number: 2747918-66-5
Notes: Clevidipine-d7 is intended for use as an internal standard for the quantification of clevidipine (Item No. 23025) by GC- or LC-MS. Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
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