Formulation: A solid
Formal Name: 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy-2,2,3,3,3-d5)-(11β,16β)-pregna-1,4-diene-3,20-dione
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C25H27ClD5FO5
Formula Weight: 472
Shelf life (days): 1460
CAS Number: 2280940-18-1
Notes: Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate (Item No. 21251) by GC- or LC-MS. Clobetasol propionate is a corticosteroid.{33297} It binds to glucocorticoid receptors in a cell-free assay (IC50 = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml.{33297,52985} Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice.{33297} Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions.
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