Formulation: A solid
Formal Name: N-(2,6-dichlorophenyl)-4,5-dihydro-d2-1H-imidazol-4,5-d2-2-amine, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C9H5Cl2D4N3 • HCl
Formula Weight: 270,6
Shelf life (days): 1460
CAS Number: 67151-02-4
Notes: Clonidine-d4 is intended for use as an internal standard for the quantification of clonidine (Item No. 15949) by GC- or LC-MS. Clonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 61.66, 69.18, and 134.9 nM for α2A-, α2B-, and α2C-ARs, respectively).{40326} It stimulates [35S]GTPγS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for α2A-, α2B-, and α2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).{46373} It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 μM.{25849} Clonidine (10 μM) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 μg/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} Formulations containing clonidine have been used in the treatment of hypertension.
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