Formulation: A solid
Formal Name: 1-((2-chlorophenyl)(phenyl)(phenyl-d5)methyl)-1H-imidazole
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C22H12ClD5N2
Formula Weight: 349,9
Shelf life (days): 1460
CAS Number: 1185076-41-8
Notes: Clotrimazole-d5 is intended for use as an internal standard for the quantification of clotrimazole (Item No. 15278) by GC- or LC-MS. Clotrimazole is an imidazole antifungal agent.{25589} It is active against a variety of fungi, including C. albicans, A. fumigatus, S. cerevisiae, C. neoformans, T. mentagrophytes, and M. canis (MICs = v1.3 and the intermediate conductance calcium-activated potassium channel (IKCa1/KCa3.1; IC50s = 6 and 0.07 µM, respectively) and decreases proliferation of HaCaT keratinocytes (EC50 = 15 µM).{25588} Topical application of clotrimazole (1%) reduces oxazolone-induced ear swelling in an oxazolone-sensitized mouse model of delayed-type hypersensitivity. Clotrimazole (10 µM) also inhibits proliferation of A549 lung, HT-29 colon, and MM-RU melanoma cancer cells.{53795} Formulations containing clotrimazole have been used in the treatment of fungal skin infections.
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