Formulation: A solid
Formal Name: 9a-[(4-chlorophenyl)methyl]-1,2,9,9a-tetrahydro-7-hydroxy-4-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3H-fluoren-3-one
Purity: ≥98%
Formula Markup: C33H34ClNO3
Formula Weight: 528,1
Shelf life (days): 1460
CAS Number: 851107-28-3
Notes: CMP8 is a mutant estrogen receptor α (ERα) antagonist and ligand used for bump and hole, a technique to study single protein isoforms when familial homology would interfere with other isoform-selective approaches.{67419} It is selective for an ERα triple mutant containing a lysine-to-methionine substitution at position 384 (ErαL384M), a methionine-to-glycine substitution at position 421 (ErαM421G), and a glycine-to-arginine substitution at position 521 (ErαG521R), over wild-type ERα and ERβ (IC50s= 29, 1,085, and 2,232 nM, respectively). It reduces reporter gene expression in HeLa cells expressing the triple mutant ERα (EC50 = 41 nM).
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