Notes: Cortexolone 17α-propionate is a peripherally selective androgen receptor antagonist.{45540} Cortexolone 17α-propionate binds to the androgen receptor (AR) and inhibits AR-regulated transcription in a reporter assay.{45539} It also inhibits androgen-regulated lipid synthesis in primary human sebocytes. Cortexolone 17α-propionate inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells.{45539,45538} It inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84% when administered topically at a dose of 400 μg/animal.