Formulation: A crystalline solid
Formal Name: (αE,2S,3S,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester
Purity: ≥98%
Formula Markup: C22H28N2O3
Formula Weight: 368,5
Shelf life (days): 730
CAS Number: 23407-35-4
Notes: Corynantheidine is an alkaloid that has been found in M. speciosa (Kratom in Thai) and has antinociceptive activity.{67185,67186} It is a partial agonist of the μ-opioid receptor that lacks β-arrestin recruitment activity.{67185} Corynantheidine selectively binds to μ-opioid receptors over κ- and δ-opioid receptors (Kis = 57.1, 385.4, and 172 nM, respectively, for the mouse receptors) and is selective for the μ-opioid receptor (EC50 = 104.24 nM) over the κ- and δ-opioid receptors, for which it has no activity, in [35S]GTPγS assays. It also binds to α1D- and α2A-adrenergic receptors and NMDA receptors (Kis = 41, 74, and 83 nM, respectively, for the human receptors), among others.{67185,67186} Corynantheidine (10-100 nmol, i.c.v.) increases the latency to tail withdrawal in the tail-flick test in mice.{67185}
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