Formulation: A crystalline solid
Formal Name: 4-hydroxy-αS-(4-hydroxyphenyl)-βS-methyl-4-phenyl-1-piperidineethanol
Purity: ≥98%
Formula Markup: C20H25NO3
Formula Weight: 327,4
Shelf life (days): 1460
CAS Number: 134234-12-1
Notes: CP 101,606 is a noncompetitive antagonist of NMDA receptors containing the NR2B subunit (Kd = 4.2 nM).{39515} CP 101,606 is highly selective for NR1/NR2B-containing NMDA receptors over NR1, NR2A, and NR2B subunits alone and NR1/NR2A receptors in HEK293 cell homogenates. In vivo, CP 101,606 (30 mg/kg, s.c.) inhibits mechanical hyperalgesia following carrageenan challenge in rats.{39516} It also inhibits licking behavior in rats induced by capsaicin (Item No. 92350) and phorbol-12-myristate-13-acetate (PMA; Item No. 10008014; ED50s = 7.5 and 5.7 mg/kg, respectively). CP 101,606 reverses catalepsy in rats induced by haloperidol (Item No. 12014) with an ED50 value of 0.4 mg/kg.{39517} CP 101,606 (1 mg/kg, s.c.) alone or in combination with L-DOPA methyl ester (Item No. 16149) temporarily improves parkinsonian symptoms in an MPTP model of Parkinson's disease in rhesus monkeys.
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