Formulation: A solid
Formal Name: 1-[(3S,4R)-3-([1,1′-biphenyl]-4-ylmethyl)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-7-yl]-cyclopentanecarboxylic acid
Purity: ≥98%
Formula Markup: C28H28O4
Formula Weight: 428,5
Shelf life (days): 1460
CAS Number: 158081-99-3
Notes: CP 105,696 is an antagonist of the leukotriene B4 (LTB4) receptor (IC50 = 8.42 nM for the high-affinity receptor in human neutrophils).{51624} It inhibits chemotaxis induced by LTB4 (Item No. 20110) in isolated human neutrophils (IC50 = 5 nM) and LTB4-induced calcium mobilization in isolated human monocytes (IC50 = 940 nM). CP 105,696 reduces infiltration of neutrophils and eosinophils induced by arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) in guinea pig skin (ED50 = 0.3 mg/kg, p.o.). It decreases blood glucose levels in the glucose tolerance test and reduces hepatic steatosis in a mouse model of obesity induced by a high-fat diet.{28488} CP 105,696 decreases disease severity in a mouse model of experimental allergic encephalomyelitis (EAE; ED50 = 8.6 mg/kg).{51626} It increases graft survival in a mouse model of allogeneic heart transplantation when administered at a dose of 50 mg/kg.{51625}
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