Formulation: A crystalline solid
Formal Name: 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-pyrazine, monohydrochloride
Purity: ≥95%
Formula Markup: C15H17ClN4O • HCl
Formula Weight: 341,2
Shelf life (days): 1460
CAS Number: 1215721-40-6
Notes: CP 809,101 is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT2C.{36583} It is selective for human 5-HT2C and rat 5-HT2C over human 5-HT2A, 5-HT2B, and rat 5-HT2A receptors in a FLIPR membrane potential assay (EC50s = 0.11, 0.06, 153, 65.3, and 119 nM, respectively) as well as human dopamine D2, histamine H1, and α1- and α2-adrenergic receptors (Kis = 872, 828, 217, and 956 nM, respectively). CP 809,101 inhibits the conditioned avoidance response, hyperactivity induced by PCP and D-amphetamine, and spontaneous locomotor activity in rats (ED50s = 4.8, 2.4, 2.9, and 2 mg/kg, respectively). It reduces prepulse inhibition deficits induced by apomorphine and improves novel object recognition in mice. CP 809,101 (0.01-1 μg/0.2 μl/side) reduces reinstatement of drug-seeking behavior in cocaine-primed rats when administered into the central amygdala but not the basolateral amygdala.{36584} It also reduces reinstatement of food-seeking behavior in a rat model of dietary relapse.{36585}
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