(cPP1-7,NPY19-23,Ala31,Aib32,Gln34) - Pancreatic Polypeptide (human) (acetate)

Formulation: A crystalline solid

Formal Name: glycyl-L-prolyl-L-seryl-L-glutaminyl-L-prolyl-L-threonyl-L-tyrosyl-L-prolylglycyl-L-α-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-seryl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-alanyl-2-methylalanyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide, acetate

Purity: ≥98%

Formula Markup: C183H281N57O54S2 • XC2H4O2

Formula Weight: 4207,7

Shelf life (days): 1460

Notes: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide is an agonist of the neuropeptide Y (NPY) receptor Y5.{67407} It inhibits cAMP production induced by forskolin (Item No. 11018) in HEK293 cells expressing the human Y5 receptor (EC50 = 17 nM). [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide selectively binds to Y5 (IC50 = 0.24 nM in HEK293 cells expressing the human receptor) over Y1, Y2, and Y4 (IC50s = 530, >500, and 51 nM, respectively, in BHK-21 cells expressing the human receptors). In vitro, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide increases VEGF levels, as well as endothelial branch length and the number of branch points, in 4T1 murine mammary carcinoma cells in a concentration-dependent manner.{67408} It induces relaxation of vasopressin-precontracted rat mesenteric arteries when used at a concentration of 1 µM.{67409} Intracranial administration of [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide (0.2 and 2 nmol/animal) increases food intake in rats.{67407}

• SKU: CAY36718-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36718-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK