Formulation: A neat oil
Formal Name: N-ethyl-N-(2-methylphenyl)-2-butenamide
Purity: ≥95%
Formula Markup: C13H17NO
Formula Weight: 203,3
Shelf life (days): 1460
CAS Number: 483-63-6
Notes: Crotamiton is an ectoparasiticide and antipruritic agent.{41525,41526,41527} It blocks the mouse transient receptor potential vanilloid 4 (TRPV4) channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium, respectively).{41526} It inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A (Item No. 17289). Topical application of crotamiton (0.025 g of a 10% ointment) also inhibits scratching behavior in mice induced by histamine, serotonin (Item No. 14332), and the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. 16723).{41527} Formulations containing crotamiton have been used to eradicate scabies and in the treatment of symptomatic pruritic skin.
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