CU-115, CAS 2471982-20-2

Formulation: A crystalline solid

Formal Name: N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo-benzamide

Purity: ≥98%

Formula Markup: C21H11F7INO2

Formula Weight: 569,2

Shelf life (days): 730

CAS Number: 2471982-20-2

Notes: CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC50 = 1.04 µM).{50809} It is selective for TLR8 over TLR7 (IC50 = >50 µM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20 µM. It decreases TNF-α and IL-1β production induced by R-848 (Item No. 14806) in THP-1 cells when used at a concentration of 5 µM.

• SKU: CAY29815-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29815-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK