CU-CPT17e, CAS 2109805-75-4

Formulation: A solid

Formal Name: 2′,3′,5′,6′-tetrahydro-6,7-bis[(4-nitrophenyl)methoxy]-spiro[2H-1-benzopyran-2,4′-[4H]pyran]

Purity: ≥95%

Formula Markup: C27H24N2O8

Formula Weight: 504,5

Shelf life (days): 1460

CAS Number: 2109805-75-4

Notes: CU-CPT17e is an agonist of toll-like receptor 3 (TLR3), TLR8, and TLR9.{69529} It selectively induces NF-κB activation in HEK293 cells expressing recombinant human TLR3, TLR8, or TLR9 (EC50s = 4.8, 13.45, and 5.66 µM, respectively) over HEK293 cells expressing recombinant human TLR2, TLR4, TLR5, or TLR7 (EC50s = >100 µM for all). CU-CPT17e (5-40 µM) induces TNF-α, IL-6, and IL-8 production in THP-1 cells. It also inhibits the growth of HeLa cells (IC50 = 2.71 µM).

• SKU: CAY39534-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39534-5
• Package Unit: 5 mg
• Quantity Unit: STK