Notes: CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8).{35162} It inhibits activation of NF-κB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells.