CU-T12-9, CAS 1821387-73-8

Formulation: A solid

Formal Name: N-methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-benzenamine

Purity: ≥98%

Formula Markup: C17H13F3N4O2

Formula Weight: 362,3

Shelf life (days): 1460

CAS Number: 1821387-73-8

Notes: CU-T12-9 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.{58194} It is selective for TLR1/2 over the TLR2/6 heterodimer in a secreted alkaline phosphatase (SEAP) assay at concentrations up to 10 µg/ml using HEK-Blue cells expressing human TLR2 and endogenously expressing both TLR1 and TLR6 and anti-TLR antibodies. CU-T12-9 (5 µM) induces NF-κB signaling in a reporter assay. It also increases nitric oxide (NO) production in RAW 264.7 cells and primary rat macrophages at 3.6 and 0.4 µM, respectively, and TNF-α production in RAW 264.7 cells (EC50 = 0.06 µM).

• SKU: CAY32867-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 32867-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK