Formulation: A solid
Formal Name: (3S,3aS,5S,6R,8aS)-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol
Purity: ≥95%
Formula Markup: C15H24O2
Formula Weight: 236,4
Shelf life (days): 1460
CAS Number: 4871-97-0
Notes: Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.{48354,48355,48356,48357} It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.{48354} Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.{48355} It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner.{48356} In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Item No. 13104).{48357}
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