Formulation: A solid
Formal Name: 1-(diphenylmethyl)-4-methyl-piperazine, monohydrochloride
Purity: ≥98%
Formula Markup: C18H22N2 • HCl
Formula Weight: 302,8
Shelf life (days): 1460
CAS Number: 303-25-3
Notes: Cyclizine is a histamine H1 receptor antagonist.{52784,52785,46616} It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).{46616} Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM.{52786} It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.{52785} Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.{52787}
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