Cyclo(L-Leu-L-Trp), CAS 15136-34-2

Formulation: A solid

Formal Name: 3S-(1H-indol-3-ylmethyl)-6S-(2-methylpropyl)-2,5-piperazinedione

Purity: ≥95%

Formula Markup: C17H21N3O2

Formula Weight: 299,4

Shelf life (days): 1460

CAS Number: 15136-34-2

Notes: Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium.{39706} It is active against various bacteria (MICs = 125-1000 µg/ml) and fungi (MICs = 8-64 µg/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 µM).{39707,39708} Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM.{39709} It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 µM, an effect that is blocked by the melatonin receptor antagonist luzindole (Item No. 15998).{39710}

• SKU: CAY24942-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 24942-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK