CYM 5478, CAS 870762-83-7

Formulation: A crystalline solid

Formal Name: 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-5-(trifluoromethyl)-2(1H)-pyridinone

Purity: ≥98%

Formula Markup: C21H19F3N2O2

Formula Weight: 388,4

Shelf life (days): 730

CAS Number: 870762-83-7

Notes: CYM 5478 is a sphingosine-1-phosphate receptor 2 (S1P2) agonist (EC50 = 0.78 μM in a reporter assay).{52124} It is selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively). CYM 5478 (0.1-10 μM) reduces serum starvation-induced decreases in C6 rat glioma cell viability. It also reduces accumulation of reactive oxygen species (ROS) and apoptosis induced by cisplatin (Item No. 13119) in C6 cells when used at a concentration of 10 μM.

• SKU: CAY29024-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29024-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK