D-Kynurenine, CAS 13441-51-5

Formulation: A crystalline solid

Formal Name: αR,2-diamino-γ-oxo-benzenebutanoic acid

Purity: ≥98%

Formula Markup: C10H12N2O3

Formula Weight: 208,2

Shelf life (days): 1460

CAS Number: 13441-51-5

Notes: D-Kynurenine is an antagonist of hydroxycarboxylic acid receptor 3 HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan.{46426} It increases levels of intracellular calcium and decreases forskolin-stimulated production of cAMP in CHO cells expressing human HCA3/GPR109B when used at concentrations of 10 and 100, or 1,000 µM, respectively. D-Kynurenine (10 µM) increases expression of vimentin and decreases expression of E-cadherin in 95D lung cancer cells.{46427} It has been used as a substrate in fluorometric assays for D-amino acid oxidase activity.{46428,46429}

• SKU: CAY28254-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28254-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK