D-myo-Inositol-1,3,4-triphosphate (sodium salt)

Formulation: A lyophilized powder

Formal Name: D-myo-inositol-1,3,4-tris(dihydrogen phosphate), trisodium salt

Purity: ≥98%

Formula Markup: C6H12O15P3 • 3Na

Formula Weight: 486

Shelf life (days): 1825

Notes: The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.{8672,8344} D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels.{8674} The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium.{9102} The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.{5714}

• SKU: CAY60972-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 60972-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK