Formulation: A solid
Formal Name: 4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]-benzeneacetic acid
Purity: ≥98%
Formula Markup: C16H16ClNO4S
Formula Weight: 353,8
Shelf life (days): 1460
CAS Number: 79094-20-5
Notes: Daltroban is a thromboxane receptor (TP) antagonist.{3400} It inhibits aggregation of isolated human platelets induced by the TP agonist U-46619 (Item no. 16450; IC50 = 77 nM). Daltroban increases mean pulmonary arterial pressure (MPAP), mean arterial pressure (MAP), and hematocrit levels in anesthetized rats (ED50s = 20, 217, and 94 µg/kg, respectively). It maintains post-reinfusion MAP and superior mesenteric artery flow in a cat model of hemorrhagic shock when administered at a dose of 1 mg/kg.{64412} Daltroban (0.25-2 mg/kg) increases survival and decreases circulating platelet count in a rabbit model of sodium arachidonate-induced sudden death.{64418}
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