Formulation: A solid
Formal Name: 1-[[[5-(4-nitrophenyl-2,3,5,6-d4)-2-furanyl]methylene]amino]-2,4-imidazolidinedione
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C14H6D4N4O5
Formula Weight: 318,3
Shelf life (days): 1460
CAS Number: 2749234-17-9
Notes: Dantrolene-d4 is intended for use as an internal standard for the quantification of dantrolene (Item No. 14326) by GC- or LC-MS. Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 µM).{53099} It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 µM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 µM, respectively.{53100} It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 µg/ml) and MHS pigs (ED50 = 0.85 mg/kg).{53101,53102}. Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.
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