Formulation: A crystalline solid
Formal Name: 1-ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]-quinolinium, monoiodide
Purity: ≥98%
Formula Markup: C23H23N2 • I
Formula Weight: 454,4
Shelf life (days): 1460
CAS Number: 977-96-8
Notes: Decynium-22 is an inhibitor of monoamine transporters and organic cation transporters (OCTs).{48740} It inhibits the plasma membrane monoamine, serotonin (5-HT), norepinephrine, and dopamine monoamine transporters (IC50s = 1.1, 7.9, 30, and 12.9 µM, respectively), and OCT2 and OCT3 (IC50s = 10 and 0.2 µM, respectively) in radioligand binding assays. Decynium-22 also inhibits binding of the α1-adrenergic receptor antagonist prazosin (Item No. 15023) in mouse hippocampal homogenates (IC50 = 60 nM).{48741} It decreases the time stress-sensitive Wistar Kyoto, but not stress-resistant Long-Evans, rats spend immobile in the forced swim test, indicating antidepressant-like activity, when administered at doses of 1 and 10 µg/kg.{48742}
English
Deutsch
