Formulation: A crystalline solid
Formal Name: (5β)-3-oxo-cholan-24-oic acid
Purity: ≥95%
Formula Markup: C24H38O3
Formula Weight: 374,6
Shelf life (days): 1460
CAS Number: 1553-56-6
Notes: Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA; Item No. 20253).{48226} It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5; EC50 = 0.27 μM), vitamin D receptor (VDR; EC50 = 3 μM), and farnesoid X receptor (FXR) in cell-based reporter assays.{53582,10150} It also binds to the human pregnane X receptor (PXR; IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays when used at a concentration of 100 μM.{32396} Dehydrolithocholic acid binds to retinoic acid receptor-related orphan receptor γt (RORγt; Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay when used at a concentration of 10 μM.{53583} It inhibits the differentiation of T helper cells that express IL-17a (TH17 cells) when used at a concentration of 20 μM.
English
Deutsch
