Formulation: A solid
Formal Name: L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-valyl-glycinamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C37H52N8O10 • XCF3COOH
Formula Weight: 768,9
Shelf life (days): 1460
Notes: Deltorphin C is a peptide agonist of δ-opioid receptors (Ki = 0.15 nM) that has been found in Phyllomedusa bicolor.{46876} It is selective for δ-opioid receptors over µ- and ĸ-opioid receptors. It induces δ-opioid receptor translocation from large dense-core vesicles to the cell surface and induces calcitonin gene-related peptide (CGRP) release in isolated mouse dorsal root ganglion (DRG) cells when used at concentrations of 0.1 and 1 µM, respectively, effects that can be blocked with the δ-opioid receptor antagonist naltrindole (Item No. 9000705).{46877} Intrathecal administration of deltorphin C (0.15, 1.5, and 15 µg/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.{46878}
English
Deutsch
