(Des-His1,Glu9)-Glucagon (1-29) amide (trifluoroacetate salt)

Formulation: A lyophilized powder

Purity: ≥95%

Formula Markup: C148H221N41O47S • XCF3COOH

Formula Weight: 3358,7

Shelf life (days): 1460

Notes: [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes).{39477} It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes.{39477,39478} In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin (Item No. 13104).{39477}

• SKU: CAY24459
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 24459-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK