Formulation: A solid
Formal Name: 6-D-tryptophan-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), acetate
Purity: ≥98%
Formula Markup: C64H83N17O12 • XC2H4O2
Formula Weight: 1282,5
Shelf life (days): 1460
CAS Number: 1642579-30-3
Notes: Deslorelin is a peptide agonist of gonadotropin-releasing hormone (GnRH).{36464} It binds to the GnRH receptor (GnRHR) with a Ki value of 0.1 nM. Deslorelin decreases testicular volume, semen volume, sperm motility, and total sperm count, as well as increases the percentage of abnormal sperm, in dogs when administered via a subcutaneous implant at doses of 3, 6, and 12 mg/kg.{63143} It decreases disease severity and plasma levels of estradiol, 17-hydroxyprogesterone, and androstenedione in ferrets with adrenocortical disease (ACD) when administered at doses ranging from 3 to 4.41 mg/kg per implant.{63144} Deslorelin (4.7 mg/implant per animal) suppresses ovulation and estrus in cats.{63145} Formulations containing deslorelin have been used in the management of ACD in ferrets and ovulation regulation and artificial insemination in horses.
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