Formulation: A solid
Formal Name: 2-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-phenol
Purity: ≥90%
Formula Markup: C23H24N2O4
Formula Weight: 392,5
Shelf life (days): 1460
CAS Number: 72956-44-6
Notes: Desmethyl carvedilol is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist carvedilol (Item No. 15418).{49063,61991,61992} It is formed from carvedilol by the cytochrome P450 (CYP) isoform CYP2C9.{49063} Desmethyl carvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 µM), a mutation that results in spontaneous calcium release from the endoplasmic reticulum.{61991} It reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by isoproterenol (Item No. 15592) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively).{61992}
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