Formulation: A solid
Formal Name: γS-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate
Purity: ≥98%
Formula Markup: C16H19ClN2 • C4H4O4
Formula Weight: 390,9
Shelf life (days): 1460
CAS Number: 2438-32-6
Notes: Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro.{41542} It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM.{41541} Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM.{41539} In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.{41540} Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.
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