Formulation: A solid
Formal Name: 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
Purity: ≥98%
Formula Markup: C13H16N2
Formula Weight: 200,3
Shelf life (days): 1460
CAS Number: 113775-47-6
Notes: Dexmedetomidine is an agonist of α2-adrenergic receptors (α2-ARs).{51154} It selectively binds to α2-ARs over α1-ARs (Kis = 0.015 and 5 nM, respectively). In vivo, dexmedetomidine (50 µg/kg) prevents increases in cardiac troponin I (CTnI), a marker of myocardial injury, as well as reduces myocardial apoptosis, pyroptosis, and ferroptosis in a mouse model of sepsis induced by cecal ligation and puncture (CLP), effects that can be reversed by the α2-AR antagonist yohimbine (Item No. 19869).{66631} Dexmedetomidine (40 µg/kg) induces sedation and decreases mechanical nociception in cats.{66630} Formulations containing dexmedetomidine have been used as sedatives. This product is also available as an analytical reference standard (Item No. 38806).
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