Formulation: A solid
Formal Name: 7-chloro-3-(methyl-d3)-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C8H4ClD3N2O2S
Formula Weight: 233,7
Shelf life (days): 1460
CAS Number: 1432063-51-8
Notes: Diazoxide-d3 is intended for use as an internal standard for the quantification of diazoxide (Item No. 14576) by GC- or LC-MS. Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM in a FLIPR assay using HEK293 cells).{36318} It also activates SUR2A/Kir6.2 and SUR2B/Kir6.2 channels in HEK293T cells in a patch-clamp assay when used at concentrations of 30 and 300 µM.{48765} Diazoxide inhibits glucose-induced insulin release from isolated rat pancreatic β cells and induces relaxation of isolated rat aortic rings precontracted with potassium chloride (IC50s = 22.6 and 22.4 µM, respectively).{48766} It reduces mean arterial pressure and cerebral blood flow in spontaneously hypertensive rats when administered intravenously as a 5 mg/kg bolus dose.{48767} Diazoxide (50 mg/kg, i.p.) increases blood glucose levels in mice.{48768} Formulations containing diazoxide have been used in the treatment of hypoglycemia.
English
Deutsch
