Formulation: A solid
Formal Name: N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine, 2Z-butenedioate
Purity: ≥98%
Formula Markup: C20H24N2 • C4H4O4
Formula Weight: 408,5
Shelf life (days): 1460
CAS Number: 3614-69-5
Notes: Dimethindene is a histamine H1 receptor antagonist (Ki = 1.5 nM).{66819} It is selective for histamine H1 receptors over M1 muscarinic acetylcholine receptors (mAChRs) and the serotonin (5-HT) receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively). In vivo, dimethindene (0.1 mg/kg), alone or in combination with the osmotic agent icodextrin, decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgery-induced abdominal trauma in rabbits.{66820} Formulations containing dimethindene have been used in the treatment of dermatosis, pruritis, and nasal allergies.
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