Formulation: A crystalline solid
Formal Name: 2,2-dimethyl-propanoic acid, 1,1'-[4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene] ester, monohydrochloride
Purity: ≥98%
Formula Markup: C19H29NO5 • HCl
Formula Weight: 387,9
Shelf life (days): 1460
CAS Number: 64019-93-8
Notes: Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine.{36428} It reduces the density of cultured bovine primary trabecular meshwork cells (IC50 = 115 µM).{36424} Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 µM.{36424} In cultured bovine corneal endothelial cells, dipivefrin (28 µM) enhances calcium signaling and induces cytotoxicity.{36426,36425} Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 µM.{36427} Formulations containing dipivefrin have been used alone and in combination with β-adrenergic receptor antagonists for the treatment of glaucoma.
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